Development of statistical methods for DNA copy number analysis in cancerology.

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• Change-point detection jointly in the DNA copy number and the allelic ratio in tumor cells by penalized regression and kernel methods.

• Intra-tumoral heterogeneity model by using DNA copy number data.

2020
[1]	Frouin, A., Dandine-Roulland, C., Pierre-Jean, M., Deleuze, J.F., Ambroise, C. & Le Floch, E. Exploring the link between additive heritability and prediction accuracy from a ridge regression perspective. Frontiers in Genetics, 11:581594, Frontiers Media, 2020.
2016
[2]	Pierre-Jean, M. Development of statistical methods for DNA copy number analysis in cancerology.. , 2016. (Theses)
[3]	Celisse, A., Marot, G., Pierre-Jean, M. & Rigaill, G. New efficient algorithms for multiple change-point detection with kernels. , 2016., (working paper or preprint).
2015
[4]	Pierre-Jean, M., Rigaill, G. & Neuvial, P. Performance evaluation of DNA copy number segmentation methods. Briefings in Bioinformatics, 16(4):600-615, Oxford University Press (OUP), 2015.
[5]	Pierre-Jean, M. Non parametric DNA copy number segmentation using kernels. , 2015., (SMPGD'2015).
2014
[6]	Pierre-Jean, M., Rigaill, G. & Neuvial, P. Performance evaluation of DNA copy number segmentation methods. Briefings in Bioinformatics, 2014.
2013
[7]	Pierre-Jean, M. Joint segmentation of total DNA copy number and allelic ratios in cancer samples. , 2013., (SMPGD'2013).
[8]	Pierre-Jean, M. Change-point detection with kernel methods : application to DNA copy number signals. , 2013., (45e Journées de Statistiques de la SFDS , Toulouse).
[9]	Pierre-Jean, M. Package R jointSeg : Segmentation de données génomiques en cancérologie. , 2013., (Rencontres R , Lyon).
2012
[10]	Pierre-Jean, M. Segmentation de données génomiques en cancérologie. , 2012., (Journée annuelle du groupe Biopharmacie et Santé de la SFDS).

Poster SMPGD 2015 slides Rencontres R 2013 slides SFDS 2013 slides Groupe SSB 2013 slides SMPGD 2013 slides journée du groupe B&S de la SFDS 2012

M2 : Segmentation de données génomiques en cancérologie

* jointseg

The jointseg R package implements functions to quickly segment multivariate signals into piecewise constant profiles. A typical application is the joint segmentation of total DNA copy numbers and allelic ratios obtained from Single Nucleotide Polymorphism (SNP) microarrays in cancer studies. The package is available from R-forge and can be installed as follows from within R:

install.packages("acnr")
install.packages("jointseg")

2015/2016

1ère Année ENSIIE : Statistique paramétrique

projet

donneesProjet

2014/2015

M1 SGO : TP Démarche statistique 1

M1 SGO : TP Démarche statistique 2

1ère Année ENSIIE : Statistique paramétrique

2013/2014

M1 SGO : TP Démarche statistique 1

M1 SGO : TP Démarche statistique 2

L2 Info : TD Probabilité et statistique

2012/2013

École doctorale GAO : TP Bases statistiques pour la biologie