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Virginie Stanislas

PhD student (UEVE)
Université d'Évry Val d'Essonne
Laboratoire de Mathématiques et Modélisation d'Évry (UMR 8071)
I.B.G.B.I., 23 Bd. de France, 91037 Évry Cedex


Development of statistical methods to detect epistasis in Genome-Wide Association Studies.

Co-direction : Christophe Ambroise et Cyril Dalmasso



Research topics

  • Genome-Wide association studies.
  • Epistasis, gene-gene interaction.
  • Structured penalized regression models


  • Group Lasso Gene-Gene Eigen Epistasis (GGEE) :

The GGEE package implements the group lasso Gene-Gene Eigen Epistasis (G-GEE) method for detecting epistasis at the gene level. The proposed functions allow to compute interaction variables for each pair of gene and to fit a general model with a Group Lasso penalty. The package allows to generate gene structured genotype data and continuous phenotype. The package is available from github and can be installed as follows from within R:

# install.packages("devtools")


Stanislas, V., Dalmasso, C. & Ambroise, C. Eigen-Epistasis for detecting Gene-Gene interactions. BMC Bioinformatics, 18:54, BioMed Central, 2017. implementation
Stanislas, V., Dalmasso, C. & Ambroise, C. Eigen-Epistasis for detecting gene-gene interactions. BMC Bioinformatics, 18:np, BioMed Central, 2017. implementation

Seminars and Posters

  • Annual Conference of the International Society for Clinical Biostatistics (ISCB), Vigo, Spain, July 2017
  • Statistical Methods for Post Genomic Data (SMPGD), London, England, January 2017
  • Journées Ouvertes en Biologie, Informatique et Mathématiques (JOBIM), Lyon, June 2016
  • Journées de Statistique (JdS), Montpellier, June 2016
  • DAGStat 2016 - “Statistics under one umbrella”, Göttingen, Germany, March 2016
  • Statistical Analysis of Massive Genomic Data (SAMGD), Évry, November 2015
  • Statistique Mathématique et Applications, Fréjus, September 2015


  • L2 Bio : TD Statistique
  • L1 Math-Eco : TD Analyse Réelle
members/vstanislas/welcome.txt · Last modified: 2017/12/21 18:24 by Virginie Stanislas

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