- Productions scientifiques
Development of statistical methods to detect epistasis in Genome-Wide Association Studies.
The GGEE package implements the group lasso Gene-Gene Eigen Epistasis (G-GEE) method for detecting epistasis at the gene level. The proposed functions allow to compute interaction variables for each pair of gene and to fit a general model with a Group Lasso penalty. The package allows to generate gene structured genotype data and continuous phenotype. The package is available from github and can be installed as follows from within R:
# install.packages("devtools") devtools::install_github("vstanislas/GGEE")
Eigen-Epistasis for detecting gene-gene interactions. BMC Bioinformatics, 18:np, BioMed Central, 2017.
Eigen-Epistasis for detecting Gene-Gene interactions. BMC Bioinformatics, 18:54, BioMed Central, 2017.